The objectives of this study were conducted to investigate the anticancer activity of Nelumbo nucifera leaves of different extracts. Invitro anticancer activity expressed the percentage growth inhibition of HBL-100 cell lines and HT-29 cell line by different extract of Nelumbo nucifera in different concentration. The anticancer activity of petroleum ether, acetone, methanol and water extract of Nelumbo nucifera leaves were measured in EAC animals and compared with 5-Fluorouracil (5-FU) at a dose level of 20mg/kg body weight as a standard. Among all the extracts, Acetone extract of Nelumbo nucifera exhibited significant cytotoxicity against HBL-100. HT-29 cell lines were found to be sensitive to HBL-100. The in-vivo studies demonstrate that the acetonic extract of Nelumbo nucifera increased the life span and showed cytotoxicity towards tumor cells and restored the altered haematological parameters.
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